Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy.
FEBS Open Bio
; 11(2): 507-518, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33448693
ABSTRACT
Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage. Herein, we investigated the activity of XOR in a mouse model of aristolochic acid I (AA)-induced nephropathy, a type of nephrotoxic chronic kidney disease (CKD). A persistent decrease in renal function was observed in mice up to 4 weeks after 4 weeks of AA (2.5 mg kg-1 ) administration. Renal histology revealed an increase in tubular interstitial fibrosis over time. Although AA administration did not change XOR activity in the plasma, heart, liver, or muscle, XOR activity was persistently increased in renal tissue. Our results suggest that the renal tissue-specific increase in XOR activity is involved in the progression of tubulo-interstitial disorders, specifically fibrosis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Xantina Desidrogenase
/
Insuficiência Renal Crônica
/
Túbulos Renais
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article