Your browser doesn't support javascript.
loading
Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma.
Meakin, Ashley S; Morrison, Janna L; Bradshaw, Emma L; Holman, Stacey L; Saif, Zarqa; Gatford, Kathryn L; Wallace, Megan J; Bischof, Robert J; Moss, Timothy J M; Clifton, Vicki L.
Afiliação
  • Meakin AS; Pregnancy and Development Group, Mater Research Institute-University of Queensland, Brisbane, QLD, Australia.
  • Morrison JL; Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
  • Bradshaw EL; Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
  • Holman SL; Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
  • Saif Z; Pregnancy and Development Group, Mater Research Institute-University of Queensland, Brisbane, QLD, Australia.
  • Gatford KL; Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.
  • Wallace MJ; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
  • Bischof RJ; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
  • Moss TJM; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, 3168, Australia.
  • Clifton VL; Pregnancy and Development Group, Mater Research Institute-University of Queensland, Brisbane, QLD, Australia. Electronic address: vicki.clifton@mater.uq.edu.au.
Placenta ; 104: 232-235, 2021 01 15.
Article em En | MEDLINE | ID: mdl-33450642
ABSTRACT
Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were detected (AR-FL, AR-v1, AR-v7, and AR-45), and their expression and subcellular distribution was altered in the presence of maternal allergic asthma. These findings underscore the importance for in vivo models of maternal asthma to delineate molecular patterns that may contribute to feto-placental growth and development.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Asma / Receptores Androgênicos / Isoformas de Proteínas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Asma / Receptores Androgênicos / Isoformas de Proteínas Idioma: En Ano de publicação: 2021 Tipo de documento: Article