Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform).
J Alzheimers Dis
; 79(4): 1589-1599, 2021.
Article
em En
| MEDLINE
| ID: mdl-33459719
ABSTRACT
BACKGROUND:
Only little evidence is available on disorientation, one of the most challenging symptoms of Alzheimer's disease and related dementias.OBJECTIVES:
The aim of this study was to investigate the prevalence of disorientation in older age in association with the level of cognitive status, personal characteristics, and life events.METHODS:
Three longitudinal population-based cohort studies on cognitive health of elderly adults were harmonized (LEILA 75â+â, AgeCoDe/AgeQualiDe, AgeMooDe). Participants who completed a baseline and at least one follow-up assessment of cognitive functioning and who did not have stroke, Parkinson's disease, atherosclerosis, kidney disease, and/or alcoholism were included in the analysis (nâ=â2135, 72.6% female, mean age 80.2 years). Data was collected in standardized interviews and questionnaires with the participant, a proxy informant, and the participant's general practitioner.RESULTS:
Making three errors in the MMSE other than in the questions on orientation (MMSEwo) came with a probability of 7.8% for disorientation, making ten errors with a probability of 88.9%. A lower MMSEwo score (HR 0.75, CI 95 0.71-0.79, pâ<â0.001), older age (HR 1.11, CI 95 1.08-1.14, pâ<â0.001), and living in a nursing home (HR 1.64, CI 95 1.02-2.64, pâ=â0.042) were associated with incident disorientation. Impairments in walking (OR 2.41, CI 95 1.16-4.99, pâ=â0.018) were associated with a greater probability for prevalent disorientation. None of the life events were significant.CONCLUSION:
Our findings suggest that disorientation is primarily associated with cognitive status. Regular walking activities might possibly reduce the risk for disorientation but further research is necessary.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cognição
/
Confusão
/
Disfunção Cognitiva
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article