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Herpesvirus Infections and Risk of Parkinson's Disease.
Camacho-Soto, Alejandra; Faust, Irene; Racette, Brad A; Clifford, David B; Checkoway, Harvey; Searles Nielsen, Susan.
Afiliação
  • Camacho-Soto A; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA, acamacho-soto@wustl.edu.
  • Faust I; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Racette BA; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Clifford DB; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
  • Checkoway H; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Searles Nielsen S; Department of Family Medicine and Public Health, University of California, San Diego, California, USA.
Neurodegener Dis ; 20(2-3): 97-103, 2020.
Article em En | MEDLINE | ID: mdl-33461199
INTRODUCTION: Herpesviruses might play a role in the pathogenesis of neurodegenerative disorders. We sought to examine a possible association between alpha herpesvirus infections and Parkinson's disease. METHODS: We conducted a population-based case-control study of incident Parkinson's disease in 2009 Medicare beneficiaries age 66-90 years (89,790 cases, 118,095 randomly selected comparable controls). We classified beneficiaries with any diagnosis code for "herpes simplex" and/or "herpes zoster" in the previous 5 years as having had the respective alpha herpesviruses. In beneficiaries with Part D prescription coverage, we also identified those prescribed anti-herpetic medications. We calculated odds ratios (OR) and 95% CI between alpha herpesvirus diagnosis/treatment and Parkinson's disease with logistic regression, with adjustment for age, sex, race/ethnicity, smoking, and use of medical care. RESULTS: Parkinson's disease risk was inversely associated with herpes simplex (OR 0.79, 95% CI 0.74-0.84), herpes zoster (OR 0.88, 95% CI 0.85-0.91), and anti-herpetic medications (OR 0.87, 95% CI 0.80-0.96). CONCLUSION: Herpesvirus infection or treatment might reduce risk of Parkinson's disease, but future studies will be required to explore whether this inverse association is causal.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Infecções por Herpesviridae Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Infecções por Herpesviridae Idioma: En Ano de publicação: 2020 Tipo de documento: Article