Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome.

Nakajima, Tadashi; Dharmawan, Tommy; Kawabata-Iwakawa, Reika; Tamura, Shuntaro; Hasegawa, Hiroshi; Kobari, Takashi; Ota, Masaki; Tange, Shoichi; Nishiyama, Masahiko; Kaneko, Yoshiaki; Kurabayashi, Masahiko

Nakajima, Tadashi; Dharmawan, Tommy; Kawabata-Iwakawa, Reika; Tamura, Shuntaro; Hasegawa, Hiroshi; Kobari, Takashi; Ota, Masaki; Tange, Shoichi; Nishiyama, Masahiko; Kaneko, Yoshiaki; Kurabayashi, Masahiko.

Afiliação

Nakajima T; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Dharmawan T; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Kawabata-Iwakawa R; Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, Maebashi, Japan.
Tamura S; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Hasegawa H; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Kobari T; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Ota M; Department of Cardiovascular Medicine, National Hospital Organization Takasaki General Medical Center, Takasaki, Japan.
Tange S; Department of Cardiovascular Medicine, Japanese Red Cross Maebashi Hospital, Maebashi, Japan.
Nishiyama M; Gunma University, Maebashi, Japan.
Kaneko Y; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Kurabayashi M; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Ann Noninvasive Electrocardiol ; 26(3): e12828, 2021 05.

Article em En | MEDLINE | ID: mdl-33463855

Assuntos

Antiarrítmicos/uso terapêutico; Síndrome de Brugada/tratamento farmacológico; Síndrome de Brugada/genética; Mexiletina/uso terapêutico; Mutação/genética; Canal de Sódio Disparado por Voltagem NAV1.5/genética; Adulto; Síndrome de Brugada/diagnóstico; Eletrocardiografia; Feminino; Humanos; Masculino; Mutação/efeitos dos fármacos; Canal de Sódio Disparado por Voltagem NAV1.5/efeitos dos fármacos; Técnicas de Patch-Clamp; Gravidade do Paciente

Palavras-chave

SCN5A; Brugada syndrome; mexiletine; rescue; trafficking defect

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Brugada / Canal de Sódio Disparado por Voltagem NAV1.5 / Mexiletina / Antiarrítmicos / Mutação Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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