Chemokines, cytokines and substance use disorders.
Drug Alcohol Depend
; 220: 108511, 2021 03 01.
Article
em En
| MEDLINE
| ID: mdl-33465606
ABSTRACT
Efficacious pharmacotherapies for the treatment of substance use disorders need to be expanded and improved. Non-neuronal cells, particularly astrocytes and microglia, have emerged as therapeutic targets for the development of pharmacotherapies to treat dependence and relapse that accompanies chronic drug use. Cytokines and chemokines are neuroimmune factors expressed in neurons, astrocytes, and microglia that demonstrate promising clinical utility as therapeutic targets for substance use disorders. In this review, we describe a role for cytokines and chemokines in the rewarding and reinforcing effects of alcohol, opioids, and psychostimulants. We also discuss emerging cytokine- and chemokine-based therapeutic strategies that differ from conventional strategies directed toward transporters and receptors within the dopamine, glutamate, GABA, serotonin, and GABA systems.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Quimiocinas
/
Transtornos Relacionados ao Uso de Substâncias
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article