Identification of Celastrol as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension and Right Ventricular Failure Through Suppression of Bsg (Basigin)/CyPA (Cyclophilin A).

Kurosawa, Ryo; Satoh, Kimio; Nakata, Takashi; Shindo, Tomohiko; Kikuchi, Nobuhiro; Satoh, Taijyu; Siddique, Mohammad A H; Omura, Junichi; Sunamura, Shinichiro; Nogi, Masamichi; Takeuchi, Yutaro; Miyata, Satoshi; Shimokawa, Hiroaki

Kurosawa, Ryo; Satoh, Kimio; Nakata, Takashi; Shindo, Tomohiko; Kikuchi, Nobuhiro; Satoh, Taijyu; Siddique, Mohammad A H; Omura, Junichi; Sunamura, Shinichiro; Nogi, Masamichi; Takeuchi, Yutaro; Miyata, Satoshi; Shimokawa, Hiroaki.

Afiliação

Kurosawa R; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Satoh K; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Nakata T; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shindo T; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kikuchi N; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Satoh T; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Siddique MAH; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Omura J; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Sunamura S; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Nogi M; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takeuchi Y; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Miyata S; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shimokawa H; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Arterioscler Thromb Vasc Biol ; 41(3): 1205-1217, 2021 03.

Article em En | MEDLINE | ID: mdl-33472404

Assuntos

Basigina/antagonistas & inibidores; Ciclofilina A/antagonistas & inibidores; Hipertensão Arterial Pulmonar/tratamento farmacológico; Triterpenos/uso terapêutico; Disfunção Ventricular Direita/tratamento farmacológico; Animais; Anti-Hipertensivos/uso terapêutico; Basigina/genética; Basigina/metabolismo; Ciclofilina A/metabolismo; Modelos Animais de Doenças; Humanos; Hipóxia/complicações; Indóis/toxicidade; Camundongos; Camundongos Transgênicos; Miócitos Cardíacos/metabolismo; Triterpenos Pentacíclicos; Hipertensão Arterial Pulmonar/patologia; Hipertensão Arterial Pulmonar/fisiopatologia; Pirróis/toxicidade; Ratos; Disfunção Ventricular Direita/patologia; Disfunção Ventricular Direita/fisiopatologia

Palavras-chave

basigin; fibrosis; heart failure; hypertension, pulmonary; inflammation; mice

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Disfunção Ventricular Direita / Ciclofilina A / Basigina / Hipertensão Arterial Pulmonar Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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