Topical Application of BMS-509744, a Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase, Ameliorates Imiquimod-Induced Skin Inflammation in Mice.

Otake, Sho; Otsubaki, Tomoko; Uesato, Naofumi; Ueda, Yoshifumi; Murayama, Toshihiko; Hayashi, Mikio

Otake, Sho; Otsubaki, Tomoko; Uesato, Naofumi; Ueda, Yoshifumi; Murayama, Toshihiko; Hayashi, Mikio.

Afiliação

Otake S; Central Pharmaceutical Research Institute, Japan Tobacco Inc.
Otsubaki T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University.
Uesato N; Central Pharmaceutical Research Institute, Japan Tobacco Inc.
Ueda Y; Central Pharmaceutical Research Institute, Japan Tobacco Inc.
Murayama T; Central Pharmaceutical Research Institute, Japan Tobacco Inc.
Hayashi M; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University.

Biol Pharm Bull ; 44(4): 528-534, 2021 Apr 01.

Article em En | MEDLINE | ID: mdl-33473072

Assuntos

Imiquimode/efeitos adversos; Proteínas Tirosina Quinases/antagonistas & inibidores; Psoríase/induzido quimicamente; Psoríase/tratamento farmacológico; Animais; Complexo CD3/metabolismo; Dermatite/tratamento farmacológico; Dermatite/metabolismo; Interleucina-17/metabolismo; Interleucina-23/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Pele/metabolismo; Pele/patologia; Células Th17/efeitos dos fármacos; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

interleukin-2-inducible T cell kinase; psoriasis; topical application

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Psoríase / Proteínas Tirosina Quinases / Imiquimode Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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