Regulatory B Cells in Experimental Mouse Models of Arthritis.
Methods Mol Biol
; 2270: 361-373, 2021.
Article
em En
| MEDLINE
| ID: mdl-33479909
ABSTRACT
Regulatory B cells (Breg) have been shown to have a role in the suppression of a wide variety of immune responses, yet they are deficient or defective in autoimmune diseases such as rheumatoid arthritis. For the study of autoimmune inflammation, experimental models of arthritis have acted as a valuable tool in understanding the development of Bregs and their role in maintaining immune homeostasis. In this chapter, we will focus on the study of transitional-2 marginal zone precursor (T2-MZP) Bregs in the context of two experimental arthritis models antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA). We will specifically focus on how to induce arthritis, as well as on methods for the isolation and functional study of Bregs both in vitro and in vivo.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artrite Experimental
/
Imuno-Histoquímica
/
Linfócitos B Reguladores
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article