Association of Longitudinal Changes in NT-proBNP With Changes in Left Atrial Volume and Function: MESA.
Am J Hypertens
; 34(6): 626-635, 2021 06 22.
Article
em En
| MEDLINE
| ID: mdl-33491080
ABSTRACT
BACKGROUND:
The mechanism of left atrial (LA) remodeling is poorly understood. The aim of this longitudinal study was to investigate whether changes in NT-proBNP levels relate to alterations of LA structure and function over time in a multiethnic population.METHODS:
From the prospective cohort study, the Multi-Ethnic Study of Atherosclerosis, our analysis included 1,838 participants who underwent cardiac magnetic resonance imaging at the baseline and 10-year examinations, had NT-proBNP levels available at both time points, and did not develop heart failure, myocardial infarction, and/or atrial fibrillation. Multivariable linear regression was used to analyze the association between NT-proBNP level (log-transformed) at the 2 time points and change in LA volumes, LA emptying fractions (total, active, and passive), and LA longitudinal strain. Log NT-proBNP was categorized into Low-Low (N = 681), Low-High (N = 238), High-Low (N = 237), and High-High (N = 682) based on the median value at both time points.RESULTS:
With the Low-Low group as the reference group, the High-High group experienced a greater increase in LA maximum and minimum indexed volumes 3.1 ml/m2 (95% confidence interval 1.98, 4.20) and 2.7 ml/m2 (1.89, 3.51), respectively. The High-High group also experienced a greater decrease in LA total, passive, active emptying fraction, and longitudinal strain -3.3% (-4.46, -2.11), -0.9% (-1.80, -0.02), -4.2% (-5.55, -2.76), and -2.3% (-3.80, -0.72), respectively. The Low-High group had similar associations, but the effect sizes were not as high.CONCLUSIONS:
Adverse LA remodeling over 10 years of follow-up strongly correlates with prolonged elevated levels of intracardiac stress, as assessed by NT-proBNP levels.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Função Atrial
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Peptídeo Natriurético Encefálico
/
Átrios do Coração
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article