The Association of Fetal Congenital Cardiac Defects and Placental Vascular Malperfusion.
Pediatr Dev Pathol
; 24(3): 187-192, 2021.
Article
em En
| MEDLINE
| ID: mdl-33491545
ABSTRACT
OBJECTIVES:
Abnormal early angiogenesis appears to impact both placental disorders and fetal congenital heart defects (CHD). We sought to assess the association of placental perfusion defects (PPD) and fetal (CHD).METHODS:
Singleton pregnancies with isolated severe fetal CHD were compared to controls without congenital anomalies or maternal malperfusion (MVM) risk factors. CHD was categorized into group 1 single left ventricle morphology and transposition of the great vessels (TGA) and group 2 single right ventricle and two ventricle morphology. Malperfusion was defined as fetal vascular malperfusion (FVM), MVM, and both FVM and MVM.RESULTS:
PPD was increased for all CHD (n = 47), CHD with or without risk factors, and CHD groups compared to controls (n = 92). Overall CHD cases and CHD with risk factors had an increased risk of FVM (30% and 80% vs 14%), and MVM (43% and 50% vs 21%), respectively. MVM rates were similar in CHD with and without maternal risk factors. FVM (38% vs 14%) and MVM (44% vs 21%) were increased in Group 1. MVM (42% vs 21%) and both FVM and MVM (16% vs 3%) were increased in Group 2.CONCLUSIONS:
PPD risk is increased in severe isolated fetal CHD. The highest risk is seen in fetal CHD with maternal risk factors.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Placentárias
/
Cardiopatias Congênitas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article