Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing.
J Physiol Biochem
; 77(1): 63-73, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33495890
ABSTRACT
Skeletal muscle atrophy commonly occurs during ageing, thus pathways that regulate muscle mass may represent a potential therapeutic avenue for interventions. In this review, we explored the Hippo signalling pathway which plays an essential role in human oncogenesis and the pathway's influence on myogenesis and satellite cell functions, on supporting cells such as fibroblasts, and autophagy. YAP/TAZ was found to regulate both myoblast proliferation and differentiation, albeit with unique roles. Additionally, YAP/TAZ has different functions depending on the expressing cell type, making simple inference of their effects difficult. Studies in cancers have shown that the Hippo pathway influenced the autophagy pathway, although with mixed results. Most of the present researches on YAP/TAZ are focused on its oncogenicity and further studies are needed to translate these findings to physiological ageing. Taken together, the modulation of YAP/TAZ or the Hippo pathway in general may offer potential new strategies for the prevention or treatment of ageing.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Envelhecimento
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Músculo Esquelético
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Proteínas de Ciclo Celular
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Peptídeos e Proteínas de Sinalização Intracelular
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Sarcopenia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article