Soluble Receptors Affecting Stroke Outcomes: Potential Biomarkers and Therapeutic Tools.
Int J Mol Sci
; 22(3)2021 Jan 23.
Article
em En
| MEDLINE
| ID: mdl-33498620
ABSTRACT
Soluble receptors are widely understood to be freestanding moieties formed via cleavage from their membrane-bound counterparts. They have unique structures, are found among various receptor families, and have intriguing mechanisms of generation and release. Soluble receptors' ability to exhibit pleiotropic action by receptor modulation or by exhibiting a dual role in cytoprotection and neuroinflammation is concentration dependent and has continually mystified researchers. Here, we have compiled findings from preclinical and clinical studies to provide insights into the role of soluble/decoy receptors, focusing on the soluble cluster of differentiation 36, the soluble cluster of differentiation 163, and soluble lipoprotein-related protein 1 (sCD36, sCD163, and sLRP1, respectively) and the functions they could likely serve in the management of stroke, as they would notably regulate the bioavailability of the hemoglobin and heme after red blood cell lysis. The key roles that these soluble receptors play in inflammation, oxidative stress, and the related pharmacotherapeutic potential in improving stroke outcomes are described. The precise pleiotropic physiological functions of soluble receptors remain unclear, and further scientific investigation/validation is required to establish their respective role in diagnosis and therapy.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos de Diferenciação Mielomonocítica
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Biomarcadores
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Antígenos CD
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Receptores de Superfície Celular
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Antígenos CD36
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Acidente Vascular Cerebral
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Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article