Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent Evolution.
Genes (Basel)
; 12(2)2021 01 22.
Article
em En
| MEDLINE
| ID: mdl-33499018
ABSTRACT
The high conservation of nucleotides of the T-loop, including their chemical identity, are hallmarks of tRNAs from organisms belonging to the three Domains of Life. These structural characteristics allow the T-loop to adopt a peculiar intraloop conformation able to interact specifically with other conserved residues of the D-loop, which ultimately folds the mature tRNA in a unique functional canonical L-shaped architecture. Paradoxically, despite the high conservation of modified nucleotides in the T-loop, enzymes catalyzing their formation depend mostly on the considered organism, attesting for an independent but convergent evolution of the post-transcriptional modification processes. The driving force behind this is the preservation of a native conformation of the tRNA elbow that underlies the various interactions of tRNA molecules with different cellular components.
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Base de dados:
MEDLINE
Assunto principal:
RNA de Transferência
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Sequência de Bases
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Processamento Pós-Transcricional do RNA
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Sequência Conservada
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Evolução Molecular
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Conformação de Ácido Nucleico
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article