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Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising therapeutic approach for Prostate Cancer Prevention and intervention.
Javed, Zeeshan; Khan, Khushbukhat; Rasheed, Amna; Sadia, Haleema; Shahwani, Muhammad Naeem; Irshad, Asma; Raza, Shahid; Salehi, Bahare; Sharifi-Rad, Javad; Suleria, Hafiz A R; Cruz-Martins, Natália; Quispe, Cristina.
Afiliação
  • Javed Z; Office for Research Innovation and Commercialization, Lahore Garrison University, DHA, Sector-C, Phase VI, Lahore, Pakistan.
  • Khan K; Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), 44000, Islamabad, Pakistan.
  • Rasheed A; School of Basic Medical Sciences, Lanzhou University, 730000, Lanzhou, PR China.
  • Sadia H; Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.
  • Shahwani MN; Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.
  • Irshad A; Department of Life Sciences, University of Management Sciences, Lahore, Pakistan.
  • Raza S; Office for Research Innovation and Commercialization, Lahore Garrison University, DHA, Sector-C, Phase VI, Lahore, Pakistan.
  • Salehi B; Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. bahar.salehi007@gmail.com.
  • Sharifi-Rad J; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. javad.sharifirad@gmail.com.
  • Suleria HAR; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. javad.sharifirad@gmail.com.
  • Cruz-Martins N; School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 3010, Parkville, VIC, Australia.
  • Quispe C; Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal. ncmartins@med.up.pt.
Cancer Cell Int ; 21(1): 77, 2021 Jan 26.
Article em En | MEDLINE | ID: mdl-33499881
ABSTRACT
Prostate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs) in the progression of PC cells from an androgen-dependent to an androgen-independent state. At that stage, prostate tumors also fail to respond to currently practiced hormone therapies. So, studies in recent decades are focused on investigating the anti-tumor effects of natural compounds in PC. Curcumin is widely recognized and now of huge prestige for its anti-proliferative abilities in different types of cancer. However, its limited solubility, compatibility, and instability in the aqueous phase are major hurdles when administering. Nanoformulations have proven to be an excellent drug delivery system for various drugs and can be used as potential delivery platforms for curcumin in PC. In this review, a shed light is given on the miRNAs-mediated regulation of androgen receptor (AR) signaling and miRNA-curcumin interplay in PC, as well as on curcumin-based nanoformulations that can be used as possible therapeutic solutions for PC.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article