Parental nucleosome segregation and the inheritance of cellular identity.
Nat Rev Genet
; 22(6): 379-392, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33500558
ABSTRACT
Gene expression programmes conferring cellular identity are achieved through the organization of chromatin structures that either facilitate or impede transcription. Among the key determinants of chromatin organization are the histone modifications that correlate with a given transcriptional status and chromatin state. Until recently, the details for the segregation of nucleosomes on DNA replication and their implications in re-establishing heritable chromatin domains remained unclear. Here, we review recent findings detailing the local segregation of parental nucleosomes and highlight important advances as to how histone methyltransferases associated with the establishment of repressive chromatin domains facilitate epigenetic inheritance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nucleossomos
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Linhagem da Célula
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Padrões de Herança
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Montagem e Desmontagem da Cromatina
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Epigênese Genética
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Replicação do DNA
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article