Your browser doesn't support javascript.
loading
Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose.
Wadsworth, Jonathan D F; Joiner, Susan; Linehan, Jacqueline M; Jack, Kezia; Al-Doujaily, Huda; Costa, Helena; Ingold, Thea; Taema, Maged; Zhang, Fuquan; Sandberg, Malin K; Brandner, Sebastian; Tran, Linh; Vikøren, Turid; Våge, Jørn; Madslien, Knut; Ytrehus, Bjørnar; Benestad, Sylvie L; Asante, Emmanuel A; Collinge, John.
Afiliação
  • Wadsworth JDF; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Joiner S; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Linehan JM; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Jack K; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Al-Doujaily H; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Costa H; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Ingold T; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Taema M; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Zhang F; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Sandberg MK; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Brandner S; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
  • Tran L; Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London National Health Service Foundation Trust, London, United Kingdom.
  • Vikøren T; Norwegian Veterinary Institute, Oslo, Norway.
  • Våge J; Norwegian Veterinary Institute, Oslo, Norway.
  • Madslien K; Norwegian Veterinary Institute, Oslo, Norway.
  • Ytrehus B; Norwegian Veterinary Institute, Oslo, Norway.
  • Benestad SL; Norwegian Institute for Nature Research, Trondheim, Norway.
  • Asante EA; Norwegian Veterinary Institute, Oslo, Norway.
  • Collinge J; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
J Infect Dis ; 226(5): 933-937, 2022 09 13.
Article em En | MEDLINE | ID: mdl-33502474
ABSTRACT
Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion disease affecting cervids. In 2016, the first cases of CWD were reported in Europe in Norwegian wild reindeer and moose. The origin and zoonotic potential of these new prion isolates remain unknown. In this study to investigate zoonotic potential we inoculated brain tissue from CWD-infected Norwegian reindeer and moose into transgenic mice overexpressing human prion protein. After prolonged postinoculation survival periods no evidence for prion transmission was seen, suggesting that the zoonotic potential of these isolates is low.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Príons / Cervos / Rena / Doença de Emaciação Crônica Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Príons / Cervos / Rena / Doença de Emaciação Crônica Idioma: En Ano de publicação: 2022 Tipo de documento: Article