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A panel of eight autophagy-related long non-coding RNAs is a good predictive parameter for clear cell renal cell carcinoma.
Gui, Cheng-Peng; Cao, Jia-Zheng; Tan, Lei; Huang, Yong; Tang, Yi-Ming; Li, Peng-Ju; Chen, Yu-Hang; Lu, Jun; Yao, Hao-Hua; Chen, Zhen-Hua; Pan, Yi-Hui; Ye, Yun-Lin; Qin, Zi-Ke; Chen, Wei; Wei, Jin-Huan; Luo, Jun-Hang.
Afiliação
  • Gui CP; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Institute of Precision Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Cao JZ; Department of Urology, Affiliated Jiangmen Hospital, Sun Yat-sen University, Jiangmen, Guangdong, China.
  • Tan L; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Huang Y; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Tang YM; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Li PJ; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Chen YH; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Lu J; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Yao HH; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Chen ZH; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Pan YH; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Ye YL; Department of Urology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Qin ZK; Department of Urology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Chen W; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: chenw3@mail.sysu.edu.cn.
  • Wei JH; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: weijh23@mail.sysu.edu.cn.
  • Luo JH; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Institute of Precision Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: luojunh@mail.sysu.edu.cn.
Genomics ; 113(2): 740-754, 2021 03.
Article em En | MEDLINE | ID: mdl-33516849
Clear-cell renal cell carcinoma (ccRCC) carries a variable prognosis. Prognostic biomarkers can stratify patients according to risk, and can provide crucial information for clinical decision-making. We screened for an autophagy-related long non-coding lncRNA (lncRNA) signature to improve postoperative risk stratification in The Cancer Genome Atlas (TCGA) database. We confirmed this model in ICGC and SYSU cohorts as a significant and independent prognostic signature. Western blotting, autophagic-flux assay and transmission electron microscopy were used to verify that regulation of expression of 8 lncRNAs related to autophagy affected changes in autophagic flow in vitro. Our data suggest that 8-lncRNA signature related to autophagy is a promising prognostic tool in predicting the survival of patients with ccRCC. Combination of this signature with clinical and pathologic parameters could aid accurate risk assessment to guide clinical management, and this 8-lncRNAs signature related to autophagy may serve as a therapeutic target.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Carcinoma de Células Renais / Biomarcadores Tumorais / RNA Longo não Codificante / Neoplasias Renais Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Carcinoma de Células Renais / Biomarcadores Tumorais / RNA Longo não Codificante / Neoplasias Renais Idioma: En Ano de publicação: 2021 Tipo de documento: Article