Do some viruses use growth hormone, prolactin and their receptors to facilitate entry into cells?: Episodic evolution of hormones and receptors suggests host-virus arms races; related placental lactogens may provide protective viral decoys.
Bioessays
; 43(4): e2000268, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33521987
ABSTRACT
The molecular evolution of pituitary growth hormone and prolactin in mammals shows two unusual features episodes of markedly accelerated evolution and, in some species, complex families of related proteins expressed in placenta and resulting from multiple gene duplications. Explanations of these phenomena in terms of physiological adaptations seem unconvincing. Here, I propose an alternative explanation, namely that these evolutionary features reflect the use of the hormones (and their receptors) as viral receptors. Episodes of rapid evolution can then be explained as due to "arms races" in which changes in the hormone lead to reduced interaction with the virus, and subsequent changes in the virus counteract this. Placental paralogues of the hormones could provide decoys that bind viruses, and protect the foetus against infection. The hypothesis implies that the extensive changes introduced into growth hormone, prolactin and their receptors during the course of mammalian evolution reflect viral interactions, not endocrine adaptations.
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Base de dados:
MEDLINE
Assunto principal:
Lactogênio Placentário
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Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article