<i>Pulmonaria obscura</i> and <i>Pulmonaria officinalis</i> Extracts as Mitigators of Peroxynitrite-Induced Oxidative Stress and Cyclooxygenase-2 Inhibitors-In Vitro and In Silico Studies.

Krzyzanowska-Kowalczyk, Justyna; Kowalczyk, Mariusz; Ponczek, Michal B; Pecio, Lukasz; Nowak, Pawel; Kolodziejczyk-Czepas, Joanna

Pulmonaria obscura and Pulmonaria officinalis Extracts as Mitigators of Peroxynitrite-Induced Oxidative Stress and Cyclooxygenase-2 Inhibitors-In Vitro and In Silico Studies.

Krzyzanowska-Kowalczyk, Justyna; Kowalczyk, Mariusz; Ponczek, Michal B; Pecio, Lukasz; Nowak, Pawel; Kolodziejczyk-Czepas, Joanna.

Afiliação

Krzyzanowska-Kowalczyk J; Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, State Research Institute, Czartoryskich 8, 24-100 Pulawy, Poland.
Kowalczyk M; Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, State Research Institute, Czartoryskich 8, 24-100 Pulawy, Poland.
Ponczek MB; Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Pecio L; Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, State Research Institute, Czartoryskich 8, 24-100 Pulawy, Poland.
Nowak P; Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Kolodziejczyk-Czepas J; Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.

Molecules ; 26(3)2021 Jan 26.

Article em En | MEDLINE | ID: mdl-33530389

Assuntos

Inibidores de Ciclo-Oxigenase 2/farmacologia; Ciclo-Oxigenase 2/metabolismo; Ácido Peroxinitroso/efeitos adversos; Fenóis/farmacologia; Plasma/efeitos dos fármacos; Pulmonaria/química; Simulação por Computador; Ciclo-Oxigenase 2/química; Inibidores de Ciclo-Oxigenase 2/química; Humanos; Técnicas In Vitro; Lactatos/química; Lactatos/farmacologia; Modelos Moleculares; Conformação Molecular; Simulação de Acoplamento Molecular; Estresse Oxidativo/efeitos dos fármacos; Fenóis/química; Compostos Fitoquímicos; Componentes Aéreos da Planta/química; Extratos Vegetais/química; Extratos Vegetais/farmacologia; Plasma/química

Palavras-chave

Pulmonaria; anti-inflammatory; antioxidant; blood plasma; cyclooxygenase-2; menisdaurin; peroxynitrite; salvianolic acid H

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenóis / Plasma / Pulmonaria / Ácido Peroxinitroso / Ciclo-Oxigenase 2 / Inibidores de Ciclo-Oxigenase 2 Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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