Engineering polysialic acid on Schwann cells using polysialyltransferase gene transfer or purified enzyme exposure for spinal cord injury transplantation.

Pearse, Damien D; Rao, Sudheendra N R; Morales, Alejo A; Wakarchuk, Warren; Rutishauser, Urs; El-Maarouf, Abderrahman; Ghosh, Mousumi

Pearse, Damien D; Rao, Sudheendra N R; Morales, Alejo A; Wakarchuk, Warren; Rutishauser, Urs; El-Maarouf, Abderrahman; Ghosh, Mousumi.

Afiliação

Pearse DD; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, 33136, USA; The Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA; The Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL,
Rao SNR; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Morales AA; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Wakarchuk W; Department of Biological Sciences, University of Alberta, Edmonton, AB, TG6 2E9, Canada.
Rutishauser U; Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, USA.
El-Maarouf A; Prothena Biosciences, South San Francisco, CA, USA.
Ghosh M; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, 33136, USA; The Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA; Department of Veterans Affairs, Veterans Affairs Medical Center, Miami, FL, 33136,

Neurosci Lett ; 748: 135690, 2021 03 23.

Article em En | MEDLINE | ID: mdl-33540059

Assuntos

Movimento Celular/efeitos dos fármacos; Células de Schwann/efeitos dos fármacos; Ácidos Siálicos/farmacologia; Sialiltransferases/efeitos dos fármacos; Traumatismos da Medula Espinal/tratamento farmacológico; Animais; Movimento Celular/fisiologia; Modelos Animais de Doenças; Camundongos; Moléculas de Adesão de Célula Nervosa; Recuperação de Função Fisiológica/efeitos dos fármacos; Recuperação de Função Fisiológica/fisiologia; Células de Schwann/metabolismo; Sialiltransferases/genética; Traumatismos da Medula Espinal/fisiopatologia

Palavras-chave

Axon growth; Cell migration; Polysialic acid; Polysialytransferase; Schwann cell transplantation; Spinal cord injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células de Schwann / Ácidos Siálicos / Sialiltransferases / Traumatismos da Medula Espinal / Movimento Celular Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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