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Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions.
Marais, Ben J; Cheong, Elaine; Fernando, Shelanah; Daniel, Santhosh; Watts, Matthew R; Berglund, Lucinda J; Barry, Simone E; Kotsiou, George; Headley, Alex P; Stapledon, Richard A.
Afiliação
  • Marais BJ; The Marie Bashir Institute for Infectious Diseases and Biosecurity (MBI), University of Sydney, Sydney, Australia.
  • Cheong E; Department of Infectious Diseases and Microbiology, Concord Repatriation General Hospital, Sydney, Australia.
  • Fernando S; Department of Microbiology and Infectious Diseases, Royal North Shore Hospital, Sydney, Australia.
  • Daniel S; Department of Infectious Diseases and Microbiology, Flinders Medical Centre and Flinders University, Adelaide, Australia.
  • Watts MR; The Marie Bashir Institute for Infectious Diseases and Biosecurity (MBI), University of Sydney, Sydney, Australia.
  • Berglund LJ; Centre for Infectious Diseases and Microbiology Infectious Diseases and Microbiology (CIDM), Westmead Hospital, Sydney, Australia.
  • Barry SE; ICPMR Westmead Hospital, NSW Health Pathology, Sydney, Australia.
  • Kotsiou G; The Marie Bashir Institute for Infectious Diseases and Biosecurity (MBI), University of Sydney, Sydney, Australia.
  • Headley AP; ICPMR Westmead Hospital, NSW Health Pathology, Sydney, Australia.
  • Stapledon RA; Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia.
Open Forum Infect Dis ; 8(1): ofaa604, 2021 Jan.
Article em En | MEDLINE | ID: mdl-33542942
ABSTRACT
We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article