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Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.
Silva de Castro, Isabela; Gorini, Giacomo; Mason, Rosemarie; Gorman, Jason; Bissa, Massimiliano; Rahman, Mohammad A; Arakelyan, Anush; Kalisz, Irene; Whitney, Stephen; Becerra-Flores, Manuel; Ni, Eric; Peachman, Kristina; Trinh, Hung V; Read, Michael; Liu, Mei-Hue; Van Ryk, Donald; Paquin-Proulx, Dominic; Shubin, Zhanna; Tuyishime, Marina; Peele, Jennifer; Ahmadi, Mohammed S; Verardi, Raffaello; Hill, Juliane; Beddall, Margaret; Nguyen, Richard; Stamos, James D; Fujikawa, Dai; Min, Susie; Schifanella, Luca; Vaccari, Monica; Galli, Veronica; Doster, Melvin N; Liyanage, Namal P M; Sarkis, Sarkis; Caccuri, Francesca; LaBranche, Celia; Montefiori, David C; Tomaras, Georgia D; Shen, Xiaoying; Rosati, Margherita; Felber, Barbara K; Pavlakis, George N; Venzon, David J; Magnanelli, William; Breed, Matthew; Kramer, Josh; Keele, Brandon F; Eller, Michael A; Cicala, Claudia; Arthos, James.
Afiliação
  • Silva de Castro I; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Gorini G; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Mason R; ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Gorman J; Structural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Bissa M; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Rahman MA; Immune Biology of Retroviral Infection Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Arakelyan A; Section on Intercellular Interactions, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kalisz I; Advanced Bioscience Laboratories, Rockville, MD 20850, USA.
  • Whitney S; Advanced Bioscience Laboratories, Rockville, MD 20850, USA.
  • Becerra-Flores M; New York University School of Medicine, NYU Langone Health, New York, NY 10016, USA.
  • Ni E; New York University School of Medicine, NYU Langone Health, New York, NY 10016, USA.
  • Peachman K; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Trinh HV; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Read M; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Liu MH; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Van Ryk D; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Paquin-Proulx D; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Shubin Z; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Tuyishime M; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Peele J; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Ahmadi MS; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Verardi R; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Hill J; Division of Surgical Sciences, Duke University School of Medicine, Durham, NC 27701, USA.
  • Beddall M; Division of Surgical Sciences, Duke University School of Medicine, Durham, NC 27701, USA.
  • Nguyen R; Structural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Stamos JD; Structural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Fujikawa D; ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Min S; ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Schifanella L; ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Vaccari M; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Galli V; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Doster MN; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Liyanage NPM; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Sarkis S; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Caccuri F; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • LaBranche C; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Montefiori DC; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Tomaras GD; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Shen X; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
  • Rosati M; Division of Surgical Sciences, Duke University School of Medicine, Durham, NC 27701, USA.
  • Felber BK; Division of Surgical Sciences, Duke University School of Medicine, Durham, NC 27701, USA.
  • Pavlakis GN; Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
  • Venzon DJ; Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
  • Magnanelli W; Human Retrovirus Section, National Cancer Institute, Frederick, MD 21702, USA.
  • Breed M; Human Retrovirus Pathogenesis Section, National Cancer Institute, Frederick, MD 21702, USA.
  • Kramer J; Human Retrovirus Section, National Cancer Institute, Frederick, MD 21702, USA.
  • Keele BF; Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Eller MA; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD 21704, USA.
  • Cicala C; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD 21704, USA.
  • Arthos J; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD 21704, USA.
iScience ; 24(2): 102047, 2021 Feb 19.
Article em En | MEDLINE | ID: mdl-33554060
The efficacy of ALVAC-based HIV and SIV vaccines in humans and macaques correlates with antibodies to envelope variable region 2 (V2). We show here that vaccine-induced antibodies to SIV variable region 1 (V1) inhibit anti-V2 antibody-mediated cytotoxicity and reverse their ability to block V2 peptide interaction with the α4ß7 integrin. SIV vaccines engineered to delete V1 and favor an α helix, rather than a ß sheet V2 conformation, induced V2-specific ADCC correlating with decreased risk of SIV acquisition. Removal of V1 from the HIV-1 clade A/E A244 envelope resulted in decreased binding to antibodies recognizing V2 in the ß sheet conformation. Thus, deletion of V1 in HIV envelope immunogens may improve antibody responses to V2 virus vulnerability sites and increase the efficacy of HIV vaccine candidates.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article