Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-&#954;B/NLRP3/IL-1ß Pathway in Macrophages.

Guan, Fei; Jiang, Wangfang; Bai, Yang; Hou, Xiao; Jiang, Chunjie; Zhang, Chongyang; Jacques, Muziazia Lupemba; Liu, Wenqi; Lei, Jiahui

Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-κB/NLRP3/IL-1ß Pathway in Macrophages.

Guan, Fei; Jiang, Wangfang; Bai, Yang; Hou, Xiao; Jiang, Chunjie; Zhang, Chongyang; Jacques, Muziazia Lupemba; Liu, Wenqi; Lei, Jiahui.

Afiliação

Guan F; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jiang W; Department of Clinical Laboratory, Changzhi People's Hospital, Changzhi, China.
Bai Y; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hou X; Department of Clinical Laboratory, General Hospital of Central Theater Command, PLA, Wuhan, China.
Jiang C; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang C; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jacques ML; Department of Parasitology, School of Basic Medicine, Institute of Medical Technology, Kinshasa, Democratic Republic of the Congo.
Liu W; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lei J; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China leijiahui@hotmail.com.

Infect Immun ; 89(5)2021 04 16.

Article em En | MEDLINE | ID: mdl-33558327

Assuntos

Interleucina-1beta/metabolismo; Macrófagos/imunologia; Macrófagos/metabolismo; NF-kappa B/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Receptores Purinérgicos P2X7/metabolismo; Transdução de Sinais; Trichinella spiralis; Animais; Modelos Animais de Doenças; Expressão Gênica; Mucosa Intestinal/metabolismo; Mucosa Intestinal/parasitologia; Mucosa Intestinal/patologia; Camundongos; Camundongos Knockout; Carga Parasitária; Antagonistas do Receptor Purinérgico P2X/farmacologia; Receptores Purinérgicos P2X7/genética; Triquinelose/imunologia; Triquinelose/metabolismo; Triquinelose/parasitologia

Palavras-chave

IL-1ß; NF-κB; NLPR3; P2X7R; Trichinella spiralis; macrophages

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / NF-kappa B / Trichinella spiralis / Interleucina-1beta / Receptores Purinérgicos P2X7 / Proteína 3 que Contém Domínio de Pirina da Família NLR / Macrófagos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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