Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes.

Medzikovic, Lejla; Heese, Hylja; van Loenen, Pieter B; van Roomen, Cindy P A A; Hooijkaas, Ingeborg B; Christoffels, Vincent M; Creemers, Esther E; de Vries, Carlie J M; de Waard, Vivian

Medzikovic, Lejla; Heese, Hylja; van Loenen, Pieter B; van Roomen, Cindy P A A; Hooijkaas, Ingeborg B; Christoffels, Vincent M; Creemers, Esther E; de Vries, Carlie J M; de Waard, Vivian.

Afiliação

Medzikovic L; Department of Medical Biochemistry, Amsterdam University Medical Centers (Amsterdam UMC), Location Academic Medical Center (AMC), Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Heese H; Department of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA.
van Loenen PB; Department of Medical Biochemistry, Amsterdam University Medical Centers (Amsterdam UMC), Location Academic Medical Center (AMC), Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
van Roomen CPAA; Department of Medical Biochemistry, Amsterdam University Medical Centers (Amsterdam UMC), Location Academic Medical Center (AMC), Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Hooijkaas IB; Department of Medical Biochemistry, Amsterdam University Medical Centers (Amsterdam UMC), Location Academic Medical Center (AMC), Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Christoffels VM; Department of Medical Biology, Amsterdam UMC, Location AMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Creemers EE; Department of Medical Biology, Amsterdam UMC, Location AMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
de Vries CJM; Department of Experimental Cardiology, Amsterdam UMC, Location AMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
de Waard V; Department of Medical Biochemistry, Amsterdam University Medical Centers (Amsterdam UMC), Location Academic Medical Center (AMC), Amsterdam Cardiovascular Sciences, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Int J Mol Sci ; 22(4)2021 Feb 05.

Article em En | MEDLINE | ID: mdl-33562500

Assuntos

Cardiomiopatias/metabolismo; Miócitos Cardíacos/metabolismo; Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares/metabolismo; Animais; Cardiomiopatias/genética; Cardiomiopatias/patologia; Células Cultivadas; Colágeno/metabolismo; Modelos Animais de Doenças; Fibroblastos/metabolismo; Fibroblastos/patologia; Fibrose; Técnicas de Silenciamento de Genes; Ruptura Cardíaca/genética; Ruptura Cardíaca/metabolismo; Ruptura Cardíaca/patologia; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Knockout para ApoE; Modelos Cardiovasculares; Miocárdio/metabolismo; Miocárdio/patologia; Miócitos Cardíacos/patologia; Miofibroblastos/metabolismo; Miofibroblastos/patologia; Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares/antagonistas & inibidores; Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares/deficiência; Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares/genética; Ratos; Fator de Crescimento Transformador beta/metabolismo; Remodelação Ventricular/genética; Remodelação Ventricular/fisiologia

Palavras-chave

cardiac; cardiomyocyte; fibroblast; fibrosis; myofibroblast; nuclear receptor; transforming growth factor ß

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miócitos Cardíacos / Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares / Cardiomiopatias Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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