Early life serum neurofilament dynamics predict neurodevelopmental outcome of preterm infants.
J Neurol
; 268(7): 2570-2577, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-33566157
ABSTRACT
BACKGROUND AND PURPOSE:
To determine whether neurofilament light chain (NfL), a promising serum and cerebrospinal fluid (CSF) biomarker of neuroaxonal damage, predicts functional outcome in preterm infants with neonatal brain injury.METHODS:
Our prospective observational study used a sensitive single-molecule array assay to measure serum and CSF NfL concentrations in preterm infants with moderate to severe peri/intraventricular hemorrhage (PIVH). We determined temporal serum and CSF NfL profiles from the initial diagnosis of PIVH until term-equivalent age and their association with clinical and neurodevelopmental outcome until 2 years of age assessed by Bayley Scales of Infant Development (3rd edition). We fitted univariate and multivariate logistic regression models to determine risk factors for poor motor and cognitive development.RESULTS:
The study included 48 infants born at < 32 weeks of gestation. Median serum NfL (sNfL) at PIVH diagnosis was 251 pg/mL [interquartile range (IQR) 139-379], decreasing markedly until term-equivalent age to 15.7 pg/mL (IQR 11.1-33.5). CSF NfL was on average 113-fold higher (IQR 40-211) than corresponding sNfL values. Additional cerebral infarction (n = 25)-but not post-hemorrhagic hydrocephalus requiring external ventricular drainage (n = 29) nor any other impairment-was independently associated with sNfL. Multivariate logistic regression models identified sNfL as an independent predictor of poor motor outcome or death at 1 and 2 years.CONCLUSIONS:
Serum neurofilament light chain dynamics in the first weeks of life predict motor outcome in preterm infants with PIVH.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Filamentos Intermediários
/
Hidrocefalia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article