Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel.

Arnold, William R; Carnevale, Lauren N; Xie, Zili; Baylon, Javier L; Tajkhorshid, Emad; Hu, Hongzhen; Das, Aditi

Arnold, William R; Carnevale, Lauren N; Xie, Zili; Baylon, Javier L; Tajkhorshid, Emad; Hu, Hongzhen; Das, Aditi.

Afiliação

Arnold WR; Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Carnevale LN; Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Xie Z; Department of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Baylon JL; Department of Biochemistry, Center for Biophysics and Quantitative Biology, Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Tajkhorshid E; Department of Biochemistry, Center for Biophysics and Quantitative Biology, Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Hu H; Department of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Das A; Department of Comparative Biosciences, Department of Biochemistry, Center for Biophysics and Quantitative Biology, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA. aditidas@illinois.edu.

Nat Commun ; 12(1): 926, 2021 02 10.

Article em En | MEDLINE | ID: mdl-33568652

Assuntos

Anti-Inflamatórios/administração & dosagem; Dopamina/administração & dosagem; Dor/tratamento farmacológico; Receptor CB1 de Canabinoide/imunologia; Receptor CB2 de Canabinoide/imunologia; Serotonina/administração & dosagem; Animais; Anti-Inflamatórios/química; Dopamina/química; Endocanabinoides/administração & dosagem; Endocanabinoides/química; Compostos de Epóxi/química; Feminino; Humanos; Interleucina-10/genética; Interleucina-10/imunologia; Interleucina-1beta/genética; Interleucina-1beta/imunologia; Interleucina-6/genética; Interleucina-6/imunologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Óxido Nitroso/imunologia; Dor/genética; Dor/imunologia; Receptor CB1 de Canabinoide/genética; Receptor CB2 de Canabinoide/genética; Serotonina/química; Canais de Cátion TRPV/genética; Canais de Cátion TRPV/imunologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Dopamina / Serotonina / Receptor CB1 de Canabinoide / Receptor CB2 de Canabinoide / Anti-Inflamatórios Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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