Thiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice.
Drug Des Devel Ther
; 15: 369-384, 2021.
Article
em En
| MEDLINE
| ID: mdl-33574656
ABSTRACT
BACKGROUND:
Peripheral inflammation leads to the development of persistent thermal hyperalgesia and mechanical allodynia associated with increased expression of interleukin-1ß (IL-1ß) in the spinal cord. The aim of the present study was to investigate the effects of thiazolidine derivatives, 1b ([2-(2-hydroxyphenyl)-1,3-thiazolidin-4-yl](morpholin-4-yl)methanone) and 1d (2-hydroxy-4-{[2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carbonyl]amino}benzoic acid), on thermal hyperalgesia, mechanical allodynia and on IL-1ß expression during carrageenan-induced inflammation in the spinal cord in mice. Inflammatory pain was induced by injecting 1% carrageenan into the right hind paw of the mice.METHODS:
The animals were administered thiazolidine derivatives, 1b and 1d (1 mg/kg, 3 mg/kg, or 10 mg/kg), intraperitoneally 30 minutes before carrageenan administration. The animals' behavior was evaluated by measuring thermal hyperalgesia, mechanical allodynia, and motor coordination. The IL-1ß expression was measured by enzyme-linked immunosorbent assay. Acute and sub-acute toxicity studies were conducted to evaluate the toxicity profile of compounds.RESULTS:
Treatment with the thiazolidine derivative, 1b and 1d, attenuated carrageenan-induced thermal hyperalgesia and mechanical allodynia at doses of 1 mg/kg, 3 mg/kg, and 10 mg/kg. No motor coordination deficits were observed in animals. The compounds also reduced IL-1ß expression in the spinal cord of mice. Acute and sub-acute toxicity studies revealed that both compounds were safe.CONCLUSION:
The compounds exhibit promising activity against inflammatory pain due to their ability to produce anti-hyperalgesic and anti-allodynic effects and to inhibit IL-1ß expression in the spinal cord.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Dor
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Tiazolidinas
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Hiperalgesia
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Inflamação
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article