Whole transcriptome sequencing and integrated network analysis elucidates the effects of 3,8-Di-O-methylellagic acid 2-O-glucoside derived from Sanguisorba offcinalis L., a novel differentiation inducer on erythroleukemia cells.

Long, Wang; Liu, Sha; Li, Xiao-Xuan; Shen, Xin; Zeng, Jing; Luo, Jie-Si; Li, Ke-Ru; Wu, An-Guo; Yu, Lu; Qin, Da-Lian; Hu, Guang-Qiang; Yang, Jing; Wu, Jian-Ming

Long, Wang; Liu, Sha; Li, Xiao-Xuan; Shen, Xin; Zeng, Jing; Luo, Jie-Si; Li, Ke-Ru; Wu, An-Guo; Yu, Lu; Qin, Da-Lian; Hu, Guang-Qiang; Yang, Jing; Wu, Jian-Ming.

Afiliação

Long W; School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
Liu S; School of Preclinical Medicine, Southwest Medical University, Luzhou 646000, China.
Li XX; School of Pharmacy, Southwest Medical University, Luzhou 646000, China; Department of Pharmacy, The Second People's Hospital of Yibin, Yibin 644000, China.
Shen X; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Zeng J; School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
Luo JS; School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
Li KR; School of Preclinical Medicine, Southwest Medical University, Luzhou 646000, China.
Wu AG; School of Pharmacy, Southwest Medical University, Luzhou 646000, China; Education Ministry Key Laboratory of Medical Electrophysiology, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chines
Yu L; School of Preclinical Medicine, Southwest Medical University, Luzhou 646000, China.
Qin DL; School of Pharmacy, Southwest Medical University, Luzhou 646000, China; Education Ministry Key Laboratory of Medical Electrophysiology, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chines
Hu GQ; School of Preclinical Medicine, Southwest Medical University, Luzhou 646000, China. Electronic address: hgq863@sina.com.
Yang J; School of Pharmacy, Southwest Medical University, Luzhou 646000, China. Electronic address: yangjing_0617@163.com.
Wu JM; School of Pharmacy, Southwest Medical University, Luzhou 646000, China; Education Ministry Key Laboratory of Medical Electrophysiology, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chines

Pharmacol Res ; 166: 105491, 2021 04.

Article em En | MEDLINE | ID: mdl-33582247

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Leucemia Eritroblástica Aguda/tratamento farmacológico; Sanguisorba; Antineoplásicos Fitogênicos/química; Diferenciação Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Regulação Leucêmica da Expressão Gênica/efeitos dos fármacos; Humanos; Leucemia Eritroblástica Aguda/genética; Leucemia Eritroblástica Aguda/patologia; Farmacologia em Rede; Sanguisorba/química; Transcriptoma/efeitos dos fármacos

Palavras-chave

3,8-Di-O-methylellagic acid 2-O-glucoside; 3,8-Di-O-methylellagic acid 2-O-glucoside (PubChem CID: 75253873); 3-O-methylellagic acid (PubChem CID: 13915428); Acute erythroid leukemia; Differentially regulated networks; Ellagic acid (PubChem CID: 5281855); Non-coding RNAs; Whole-transcriptome sequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Eritroblástica Aguda / Sanguisorba / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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