Co-occurrence of immune-mediated conditions and endometriosis among adolescents and adult women.
Am J Reprod Immunol
; 86(1): e13404, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33583078
ABSTRACT
PROBLEM:
Associations between immune dysfunction conditions (eg, systemic lupus erythematous, rheumatoid arthritis) and endometriosis have been observed in adult women, but not assessed among a younger population. We investigated the association between immune-mediated conditions and endometriosis among young women. METHOD OF STUDY This cross-sectional analysis in the Women's Health Study From Adolescence to Adulthood included 551 participants with surgically diagnosed endometriosis (median age=19) and 652 controls without endometriosis (median age=24). Participants completed an expanded Endometriosis Phenome and Biobanking Harmonization Project questionnaire. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the associations between autoimmune/inflammatory, atopic, chronic pain/fatigue, and endocrine disorders with endometriosis, adjusting for confounders.RESULTS:
Participants with any autoimmune and/or inflammatory condition had an increased odds of co-occurring endometriosis (OR 1.87; CI 0.92-3.80), as did participants with allergies (OR 1.76; CI 1.32-2.36), asthma (OR 1.35; CI 0.97-1.88), chronic fatigue syndrome and/or fibromyalgia (OR 5.81; CI 1.89-17.9), or previous mononucleosis (OR 1.75; CI 1.14-2.68). Odds of endometriosis were lower among participants with eczema (OR 0.68; CI 0.44-1.04). We observed a positive trend between the number of immune-mediated conditions and the odds of endometriosis (p-trend=0.0002). Endocrine disorders were not associated with endometriosis.CONCLUSIONS:
Among this population of adolescents and adult women, endometriosis was more likely among participants with autoimmune and/or inflammatory diseases, allergies, asthma, previous mononucleosis infection, and chronic fatigue and/or fibromyalgia. We observed that an increasing number of immune-mediated conditions were positively associated with endometriosis risk. It is important for clinicians who care for adolescents and women with these conditions to consider endometriosis as a comorbidity.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
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Fatores Etários
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Mastocitose Sistêmica
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Endometriose
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article