Difluorocarbene-based cyanodifluoromethylation of alkenes induced by a dual-functional Cu-catalyst.
Chem Commun (Camb)
; 57(21): 2649-2652, 2021 Mar 11.
Article
em En
| MEDLINE
| ID: mdl-33587731
Although cyanofluoroalkylation has received increasing attention, a toxic cyanation reagent is usually required. Herein, a Cu-catalyzed difluorocarbene-based cyanodifluoromethylation of alkenes with BrCF2CO2Et/NH4HCO3 under photocatalytic conditions is described. BrCF2CO2Et and NH4HCO3 serve as a carbon source and a nitrogen source of the nitrile group, respectively, avoiding the use of a stoichiometric toxic cyanation reagent. The Cu-complex plays a dual role. It is not only a photocatalyst, but also a coupling catalyst for the formation of a C-CN bond.
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MEDLINE
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En
Ano de publicação:
2021
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Article