MicroRNAs and Diabetes Mellitus Type 1.
Curr Diabetes Rev
; 18(2): e021421191398, 2022.
Article
em En
| MEDLINE
| ID: mdl-33588736
ABSTRACT
Type 1 diabetes mellitus is a multifactorial, progressive, autoimmune disease with a strong genetic feature that can affect multiple organs, including the kidney, eyes, and nerves. Early detection of type 1 diabetes can help critically to avoid serious damages to these organs. MicroRNAs are small RNA molecules that act in post-transcriptional gene regulation by attaching to the complementary sequence in the 3'-untranslated region of their target genes. Alterations in the expression of microRNA coding genes are extensively reported in several diseases, such as type 1 diabetes. Presenting non-invasive biomarkers for early detection of type 1 diabetes by quantifying microRNAs gene expression level can be a significant step in biotechnology and medicine. This review discusses the area of microRNAs dysregulation in type 1 diabetes and affected molecular mechanisms involved in pancreatic islet cell formation and dysregulation in the expression of inflammatory elements as well as pro-inflammatory cytokines.
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Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
/
Diabetes Mellitus Tipo 1
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article