Chemical Exchanges between Multilateral Symbionts.
Org Lett
; 23(5): 1648-1652, 2021 03 05.
Article
em En
| MEDLINE
| ID: mdl-33591189
ABSTRACT
Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Simbiose
/
Bactérias
/
Fungos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article