Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity.
Dalton Trans
; 50(9): 3161-3177, 2021 Mar 07.
Article
em En
| MEDLINE
| ID: mdl-33595015
ABSTRACT
Two Pt(iv) conjugates containing one or two molecules of perillic acid (4-isopropenylcyclohexene-1-carboxylic acid), an active metabolite of limonene, were synthesized both with traditional and microwave-assisted methods and characterized. Their antiproliferative activity was tested on a panel of human tumor cell lines. In particular, cis,cis,trans-[PtIVCl2(NH3)2(perillato)2] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number of in vitro biological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.
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1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organoplatínicos
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Pró-Fármacos
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Antineoplásicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article