KPC-12 with a L169M substitution in the Ω loop has reduced carbapenemase activity.
Eur J Clin Microbiol Infect Dis
; 40(8): 1761-1766, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-33595757
ABSTRACT
KPC-12 is a variant of KPC-2 with a L169M substitution in the Ω loop, but its resistance spectrum was not reported. blaKPC-12 was cloned, and KPC-12 exhibited significantly decreased activities against imipenem, meropenem, aztreonam, and piperacillin-tazobactam with ≥4-fold lower MICs than KPC-2. However, unlike the L169P substitution in KPC-35, activities against ceftazidime and ceftazidime-avibactam of KPC-12 were unaltered. This highlights that different substitutions at the same position of carbapenemases may have varied impact on the activity.
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MEDLINE
Assunto principal:
Proteínas de Bactérias
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Beta-Lactamases
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Farmacorresistência Bacteriana Múltipla
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Klebsiella pneumoniae
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article