The UFSP2/UFMylation Pathway Is Involved in Silica-Induced Pulmonary Injury.
DNA Cell Biol
; 40(4): 589-594, 2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-33600261
ABSTRACT
Silicosis is an irreversible occupational pulmonary disease that is characterized as progressed pulmonary fibrosis. In this study, we investigated the changes of UFSP2 and the related UFMylation in silica-induced pulmonary injury mice models. The experimental silicosis models were prepared by intratracheal injection of silica particles, and the lung samples were harvested at the first or the seventh day after treatment. We found that the UFSP2 expression in the 1-day models was comparable, whereas it was upregulated in the 7-day models. Consistently, the UFMylation in the lung tissues of the 7-day models was activated. In addition, we observed the CADM2, an adhesion molecule, was reported to associate with epithelial-mesenchymal transition, was upregulated in the lungs of 7-day models. In contrast, it remained comparable in the 1-day models. Our data indicated that the UFSP2/UFMylation pathway and the CADM2 might be involved in the silica-induced pulmonary injury.
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Base de dados:
MEDLINE
Assunto principal:
Silicose
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Cisteína Endopeptidases
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Proteínas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article