Ouabain induces memory impairment and alter the BDNF signaling pathway in an animal model of bipolar disorder: Cognitive and neurochemical alterations in BD model.

Valvassori, Samira S; Dal-Pont, Gustavo C; Varela, Roger B; Resende, Wilson R; Gava, Fernanda F; Mina, Franciele G; Budni, Josiane; Quevedo, João

Valvassori, Samira S; Dal-Pont, Gustavo C; Varela, Roger B; Resende, Wilson R; Gava, Fernanda F; Mina, Franciele G; Budni, Josiane; Quevedo, João.

Afiliação

Valvassori SS; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address: samiravalvassori@unesc.net.
Dal-Pont GC; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Varela RB; Queensland Brain Institute, The Universty of Queensland, St Lucia, QLD 4072, Australia.
Resende WR; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Gava FF; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Mina FG; Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Budni J; Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Quevedo J; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at

J Affect Disord ; 282: 1195-1202, 2021 03 01.

Article em En | MEDLINE | ID: mdl-33601696

Assuntos

Transtorno Bipolar; Ouabaína; Animais; Transtorno Bipolar/induzido quimicamente; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Cognição; Modelos Animais de Doenças; Hipocampo/metabolismo; Humanos; Ouabaína/toxicidade; Ratos; Ratos Wistar; Transdução de Sinais

Palavras-chave

BDNF; Bipolar disorder; CREB; Depression; Mania; Na(+)K(+)ATPase; Ouabain; TrkB

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ouabaína / Transtorno Bipolar Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ouabaína / Transtorno Bipolar Idioma: En Ano de publicação: 2021 Tipo de documento: Article