Kidney microRNA-21 Expression and Kidney Function in IgA Nephropathy.
Kidney Med
; 3(1): 76-82.e1, 2021.
Article
em En
| MEDLINE
| ID: mdl-33604541
ABSTRACT
RATIONALE & OBJECTIVE:
Previous studies have suggested that microRNA-21 (miR-21) plays an important role in kidney fibrosis. We examined the relationship between intrarenal miR-21 level and rate of kidney function loss in immunoglobulin A nephropathy (IgAN). STUDYDESIGN:
Prospective cohort study. SETTING &PARTICIPANTS:
40 patients with IgAN and 10 with hypertensive nephrosclerosis as controls. PREDICTORS miR-21 levels in kidney biopsy specimen and urinary sediment, quantified as ratio to the housekeeping gene.OUTCOMES:
Kidney event-free survival and rate of kidney function decline. ANALYTICAPPROACH:
Time-to-event and correlation analysis.RESULTS:
The IgAN group had significantly higher intrarenal miR-21 expression compared with the hypertensive nephrosclerosis group (1.71 [IQR, 0.99-2.77] vs 0.31 [IQR, 0.25-1.32]; P < 0.0001), but urinary miR-21 levels were similar. Intrarenal miR-21 expression had significant but modest correlation with severity of glomerulosclerosis (r = 0.293; P = 0.05) and tubulointerstitial fibrosis (r = 0.341; P = 0.03). Patients with high intrarenal miR-21 expression had significantly higher risk for developing kidney end points compared with those with low expression (log-rank test, P = 0.017). Univariate Cox analysis showed that intrarenal miR-21 expression significantly predicted the development of kidney end points (unadjusted HR, 1.586; 95% CI, 1.179-2.134; P = 0.002). However, the result was just short of statistical significance after adjusting for the severity of histologic damage (P = 0.06). There was also a significant correlation between intrarenal miR-21 expression and the slope of kidney function decline by univariate analysis (r = -0.399; P = 0.02).LIMITATIONS:
Small sample size; uncertain cellular origin of miR-21.CONCLUSIONS:
We found that intrarenal miR-21 expression is increased in patients with IgAN, modestly correlated with the severity of histologic damage, and predictive of subsequent kidney function loss.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article