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Design and Synthesis of EZH2-Based PROTACs to Degrade the PRC2 Complex for Targeting the Noncatalytic Activity of EZH2.
Liu, Zhihao; Hu, Xi; Wang, Qiwei; Wu, Xiuli; Zhang, Qiangsheng; Wei, Wei; Su, Xingping; He, Hualong; Zhou, Shuyan; Hu, Rong; Ye, Tinghong; Zhu, Yongxia; Wang, Ningyu; Yu, Luoting.
Afiliação
  • Liu Z; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • Hu X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • Wang Q; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • Wu X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • Zhang Q; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • Wei W; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • Su X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • He H; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • Zhou S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • Hu R; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
  • Ye T; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
  • Zhu Y; Department of Pharmacy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
  • Wang N; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
  • Yu L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
J Med Chem ; 64(5): 2829-2848, 2021 03 11.
Article em En | MEDLINE | ID: mdl-33606537
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalimidas / Benzamidas / Proteólise / Proteína Potenciadora do Homólogo 2 de Zeste / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalimidas / Benzamidas / Proteólise / Proteína Potenciadora do Homólogo 2 de Zeste / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article