Your browser doesn't support javascript.
loading
Melatonin-dependent changes in neurosteroids are associated with increased aggression in a seasonally breeding rodent.
Munley, Kathleen M; Trinidad, Jonathan C; Deyoe, Jessica E; Adaniya, Catherine H; Nowakowski, Andrea M; Ren, Clarissa C; Murphy, Grace V; Reinhart, John M; Demas, Gregory E.
Afiliação
  • Munley KM; Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN, USA.
  • Trinidad JC; Department of Chemistry, Indiana University, Bloomington, IN, USA.
  • Deyoe JE; Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN, USA.
  • Adaniya CH; Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN, USA.
  • Nowakowski AM; Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN, USA.
  • Ren CC; Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN, USA.
  • Murphy GV; Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN, USA.
  • Reinhart JM; Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN, USA.
  • Demas GE; Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN, USA.
J Neuroendocrinol ; 33(3): e12940, 2021 03.
Article em En | MEDLINE | ID: mdl-33615607
ABSTRACT
Aggression is a complex social behaviour that allows individuals to compete for access to limited resources (eg, mates, food and territories). Excessive or inappropriate aggression, however, has become problematic in modern societies, and current treatments are largely ineffective. Although previous work in mammals suggests that aggressive behaviour varies seasonally, seasonality is largely overlooked when developing clinical treatments for inappropriate aggression. Here, we investigated how the hormone melatonin regulates seasonal changes in neurosteroid levels and aggressive behaviour in Siberian hamsters, a rodent model of seasonal aggression. Specifically, we housed males in long-day (LD) or short-day (SD) photoperiods, administered timed s.c. melatonin injections (which mimic a SD-like signal) or control injections, and measured aggression using a resident-intruder paradigm after 9 weeks of treatment. Moreover, we quantified five steroid hormones in circulation and in brain regions associated with aggressive behaviour (lateral septum, anterior hypothalamus, medial amygdala and periaqueductal gray) using liquid chromatography-tandem mass spectrometry. SD hamsters and LD hamsters administered timed melatonin injections (LD-M) displayed increased aggression and exhibited region-specific decreases in neural dehydroepiandrosterone, testosterone and oestradiol, but showed no changes in progesterone or cortisol. Male hamsters also showed distinct associations between neurosteroids and aggressive behaviour, in which neural progesterone and dehydroepiandrosterone were positively correlated with aggression in all treatment groups, whereas neural testosterone, oestradiol and cortisol were negatively correlated with aggression only in LD-M and SD hamsters. Collectively, these results provide insight into a novel neuroendocrine mechanism of mammalian aggression, in which melatonin reduces neurosteroid levels and elevates aggressive behaviour.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Sexual Animal / Agressão / Neuroesteroides / Melatonina Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Sexual Animal / Agressão / Neuroesteroides / Melatonina Idioma: En Ano de publicação: 2021 Tipo de documento: Article