Iron intake with the risk of breast cancer among Chinese women: a case-control study.
Public Health Nutr
; 24(17): 5743-5755, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-33618790
ABSTRACT
OBJECTIVE:
The current study evaluated the associations between different forms and sources of Fe and breast cancer risk in Southern Chinese women.DESIGN:
Case-control study. We collected data on the consumption of Fe from different forms and food sources by using a validated FFQ. Multivariable logistic regression and restricted cubic spline (RCS) analysis was used to reveal potential associations between Fe intake and breast cancer risk.SETTING:
A case-control study of women at three major hospitals in Guangzhou, China.PARTICIPANTS:
From June 2007 to March 2019, 1591 breast cancer cases and 1622 age-matched controls were recruited.RESULTS:
In quartile analyses, Fe from plants and Fe from white meat intake were inversely associated with breast cancer risk, with OR of 0·65 (95 % CI 0·47, 0·89, Ptrend = 0·006) and 0·76 (95 % CI 0·61, 0·96, Ptrend = 0·014), respectively, comparing the highest with the lowest quartile. No associations were observed between total dietary Fe, heme or non-heme Fe, Fe from meat or red meat and breast cancer risk. RCS analysis demonstrated J-shaped associations between total dietary Fe, non-heme Fe and breast cancer, and reverse L-shaped associations between heme Fe, Fe from meat and Fe from red meat and breast cancer.CONCLUSION:
Fe from plants and white meat were inversely associated with breast cancer risk. Significant non-linear J-shaped associations were found between total dietary Fe, non-heme Fe and breast cancer risk, and reverse L-shaped associations were found between heme Fe, Fe from meat or red meat and breast cancer risk.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article