Synovial Alpha-defensin at Reimplantation in Two-stage Revision Arthroplasty to Rule Out Persistent Infection.
In Vivo
; 35(2): 1073-1081, 2021.
Article
em En
| MEDLINE
| ID: mdl-33622904
ABSTRACT
BACKGROUND/AIM:
Owing to the lack of a diagnostic gold standard, ruling out persistent periprosthetic joint infection (PJI) before second-stage surgery in the setting of two-stage revision arthroplasty constitutes a major challenge. We evaluated if the alpha-defensin-1 (AD-1) test could predict successful infection eradication before reimplantation of a new prosthesis. PATIENTS ANDMETHODS:
Our prospective study included 20 patients who underwent two-stage revision arthroplasty for treatment of PJI. A standard quantitative enzyme AD-1 immunoassay of synovial fluid, the synovial leukocyte esterase test and routine laboratory blood testing were performed prior to explantation and reimplantation. Treatment failure was defined according to the Delphi-based consensus criteria after a minimum follow-up of 1 year.RESULTS:
A 15% of our patients met the Delphi Criteria within 1 year. None of the markers investigated were significantly different in patients with and without reinfection.CONCLUSION:
Further research is necessary to identify biomarkers more suitable for indicating persistent infection before reimplantation.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Infecções Relacionadas à Prótese
/
Artroplastia de Quadril
/
Artroplastia do Joelho
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Alfa-Defensinas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article