Successful High-dose Chemotherapy in Combination With Autologous Peripheral Blood Stem Cell Transplantation in an Anuric Child With Neuroblastoma.
J Pediatr Hematol Oncol
; 43(8): e1156-e1158, 2021 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-33625080
ABSTRACT
No reports describe high-dose chemotherapy (HDCT) with autologous peripheral blood stem cell transplantation (auto-PBSCT) in pediatric patients with neuroblastoma and end-stage renal disease. Here, we report the case of a patient with high-risk neuroblastoma who developed anuria during treatment. HDCT with auto-PBSCT under hemodialysis, with strict attention to the ultrafiltration volume and dose modification of alkylating agents, was performed. Although the first auto-PBSCT led to engraftment failure, the second auto-PBSCT resulted in successful myeloid engraftment 8 months after anuria. This case demonstrated that HDCT with auto-PBSCT can be safely performed in children with renal failure under hemodialysis.
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Base de dados:
MEDLINE
Assunto principal:
Anuria
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Protocolos de Quimioterapia Combinada Antineoplásica
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Diálise Renal
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Transplante de Células-Tronco de Sangue Periférico
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Falência Renal Crônica
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Neuroblastoma
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article