Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.

Ahmed, Mahmoud S; Wang, Ping; Nguyen, Ngoc Uyen Nhi; Nakada, Yuji; Menendez-Montes, Ivan; Ismail, Muhammad; Bachoo, Robert; Henkemeyer, Mark; Sadek, Hesham A; Kandil, Enas S

Ahmed, Mahmoud S; Wang, Ping; Nguyen, Ngoc Uyen Nhi; Nakada, Yuji; Menendez-Montes, Ivan; Ismail, Muhammad; Bachoo, Robert; Henkemeyer, Mark; Sadek, Hesham A; Kandil, Enas S.

Afiliação

Ahmed MS; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Wang P; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Nguyen NUN; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Nakada Y; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Menendez-Montes I; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Ismail M; Department of Pharmaceutical Chemistry, The British University in Egypt, Cairo 11837, Egypt.
Bachoo R; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Henkemeyer M; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Sadek HA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; hesham.sadek@utsouthwestern.edu enas.kandil@utsouthwestern.edu.
Kandil ES; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Proc Natl Acad Sci U S A ; 118(10)2021 03 09.

Article em En | MEDLINE | ID: mdl-33627480

Assuntos

Sistema Nervoso Central/enzimologia; Clortetraciclina; Neuralgia; Inibidores de Proteínas Quinases; Receptor EphB1; Animais; Clortetraciclina/química; Clortetraciclina/farmacologia; Cristalografia por Raios X; Humanos; Masculino; Camundongos; Neuralgia/tratamento farmacológico; Neuralgia/enzimologia; Domínios Proteicos; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/farmacologia; Receptor EphB1/antagonistas & inibidores; Receptor EphB1/química; Receptor EphB1/metabolismo

Palavras-chave

EphB receptor; crystallography; drug repurposing; neuropathic pain

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Nervoso Central / Clortetraciclina / Receptor EphB1 / Inibidores de Proteínas Quinases / Neuralgia Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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