Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods.
Catal Sci Technol
; 9(20): 5487-5503, 2019 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-33628427
ABSTRACT
Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods.
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MEDLINE
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En
Ano de publicação:
2019
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Article