Uropathogenic E. coli induces DNA damage in the bladder.
PLoS Pathog
; 17(2): e1009310, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33630958
ABSTRACT
Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of the cleavage product released during the synthesis of colibactin, a bacterial genotoxin, in 55 of the samples examined. Uropathogenic Escherichia coli strains isolated from these patients, as well as the archetypal E. coli strain UTI89, were found to produce colibactin. In a murine model of UTI, the machinery producing colibactin was expressed during the early hours of the infection, when intracellular bacterial communities form. We observed extensive DNA damage both in umbrella and bladder progenitor cells. To the best of our knowledge this is the first report of colibactin production in UTIs in humans and its genotoxicity in bladder cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Infecções Urinárias
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Bexiga Urinária
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Dano ao DNA
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Infecções por Escherichia coli
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Escherichia coli Uropatogênica
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Policetídeos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article