Antibodies to Der p 1 and Der p 2 in allergic patients.
Allergol Immunopathol (Madr)
; 49(2): 46-52, 2021.
Article
em En
| MEDLINE
| ID: mdl-33641293
ABSTRACT
INTRODUCTION AND OBJECTIVES:
Atopic individuals are characterized by increased IgE production and Th2 response if exposed to certain antigens. It is known that the mother transfers anti-mite antibodies to the fetus and newborn, IgG thru the placenta, and IgA thru breastfeeding, but it is not clear whether there is a protective mechanism mediated by them concerning the development of future allergies. This study aimed to compare the levels of IgA, IgG, and IgE antibodies specific to Der p 1 and Der p 2 between atopic and healthy individuals.METHODS:
Serum samples of 98 patients and 44 healthy controls were subjected to quantification for specific IgE, IgG, and IgA antibodies against Der p 1 and Der p 2 by ImmunoCap® and ELISA, and subjected to statistical analysis as indicated.RESULTS:
Atopic patients had higher serum levels of IgE, IgG, and IgA specific to Der p 1 and Der p 2. The correlation was more robust between IgE and IgG antibodies.CONCLUSIONS:
Allergic patients produce higher levels of antibodies against Der p 1 and Der p 2 compared with healthy individuals. The mechanisms involved still require detailed studies.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Cisteína Endopeptidases
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Dermatophagoides pteronyssinus
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Antígenos de Dermatophagoides
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Proteínas de Artrópodes
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Hipersensibilidade Imediata
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article