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Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis.
Antunes Andrade, Fabiana; Goeldner Eibofner, Isabela; Pieczarka, Cristhine; van Tong, Hoang; Sena, Leia; Skare, Thelma; Ramos da Rosa Utiyama, Shirley; Jose de Messias-Reason, Iara; P Velavan, Thirumalaisamy.
Afiliação
  • Antunes Andrade F; Laboratory of Molecular Immunopathology, Clinic Hospital, Federal University of Paraná, Curitiba, Brazil.
  • Goeldner Eibofner I; Department of Medicine, Positive University, Curitiba, Brazil.
  • Pieczarka C; Laboratory of Molecular Immunopathology, Clinic Hospital, Federal University of Paraná, Curitiba, Brazil.
  • van Tong H; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
  • Sena L; Laboratory of Molecular Immunopathology, Clinic Hospital, Federal University of Paraná, Curitiba, Brazil.
  • Skare T; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
  • Ramos da Rosa Utiyama S; Vietnamese-German Center for Medical Research, Hanoi, Vietnam.
  • Jose de Messias-Reason I; Laboratory of Molecular Immunopathology, Clinic Hospital, Federal University of Paraná, Curitiba, Brazil.
  • P Velavan T; Rheumatology Unit, Evangelical Hospital, Curitiba, Brazil.
Int J Immunogenet ; 48(3): 260-265, 2021 Jun.
Article em En | MEDLINE | ID: mdl-33645007
ABSTRACT
The complement receptor of the immunoglobulin superfamily (CRIg, encoded by the VSIG4 gene) is a macrophage receptor involved in the clearance of immune complexes and autologous cells. Our results suggest that the VSIG4 rs1044165T allele is a risk factor for severe functional status of rheumatoid arthritis in women, possibly by affecting VSIG4 gene expression.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Receptores de Complemento / Predisposição Genética para Doença / Estudos de Associação Genética Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Receptores de Complemento / Predisposição Genética para Doença / Estudos de Associação Genética Idioma: En Ano de publicação: 2021 Tipo de documento: Article