Asymmetric synthesis and in vivo/in vitro characterization of new hybrid anticonvulsants derived from (2,5-dioxopyrrolidin-1-yl)phenylacetamides.

Abram, Michal; Rapacz, Anna; Latacz, Gniewomir; Szulczyk, Bartlomiej; Kalinowska-Tluscik, Justyna; Otto-Slusarczyk, Dagmara; Struga, Marta; Kaminski, Rafal M; Kaminski, Krzysztof

Abram, Michal; Rapacz, Anna; Latacz, Gniewomir; Szulczyk, Bartlomiej; Kalinowska-Tluscik, Justyna; Otto-Slusarczyk, Dagmara; Struga, Marta; Kaminski, Rafal M; Kaminski, Krzysztof.

Afiliação

Abram M; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Medicinal Chemistry, Medyczna 9, 30-688 Krakow, Poland.
Rapacz A; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmacodynamics, Medyczna 9, 30-688 Krakow, Poland.
Latacz G; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Medyczna 9, 30-688 Krakow, Poland.
Szulczyk B; Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.
Kalinowska-Tluscik J; Department of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Otto-Slusarczyk D; Chair and Department of Biochemistry, Medical University of Warsaw, Banacha 1, 02-091 Warsaw, Poland.
Struga M; Chair and Department of Biochemistry, Medical University of Warsaw, Banacha 1, 02-091 Warsaw, Poland.
Kaminski RM; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Medicinal Chemistry, Medyczna 9, 30-688 Krakow, Poland.
Kaminski K; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Medicinal Chemistry, Medyczna 9, 30-688 Krakow, Poland. Electronic address: k.kaminski@uj.edu.pl.

Bioorg Chem ; 109: 104751, 2021 04.

Article em En | MEDLINE | ID: mdl-33647745

Assuntos

Anticonvulsivantes/farmacologia; Convulsões/tratamento farmacológico; Animais; Anticonvulsivantes/síntese química; Anticonvulsivantes/química; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; Relação Dose-Resposta a Droga; Eletrochoque; Humanos; Masculino; Camundongos; Estrutura Molecular; Ratos; Relação Estrutura-Atividade; Canais de Sódio Disparados por Voltagem/metabolismo

Palavras-chave

ADME-Tox studies; Anticonvulsant activity; Asymmetric synthesis; Binding/functional assays; Crystallography; Electrophysiology; Enantiomers; Hybrid compounds

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Convulsões / Anticonvulsivantes Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Convulsões / Anticonvulsivantes Idioma: En Ano de publicação: 2021 Tipo de documento: Article