Positive fluid balance is associated with death and severity of brain injury in neonates with hypoxic-ischemic encephalopathy.
J Perinatol
; 41(6): 1331-1338, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33649446
ABSTRACT
OBJECTIVE:
To investigate the association between fluid balance during therapeutic hypothermia (TH) and severity of brain injury on magnetic resonance imaging (MRI) in neonates with hypoxic-ischemic encephalopathy (HIE). STUDYDESIGN:
This is a secondary analysis of data from a prospective observational study in neonates with HIE. Daily net positive fluid balance during TH was investigated for association with the adverse primary outcome of death or moderate-to-severe brain injury on MRI using multivariable logistic regression.RESULTS:
Of the 150 neonates included, 50 suffered adverse outcome and had significantly higher net positive fluid balance (53 vs. 19 ml/kg/day, p < 0.01) during first 24 hours of TH. Neonates with a net positive fluid balance (>25 ml/kg/day) at 24 hours of TH had 3.4 (95% CI 1.3-9) times higher odds of adverse outcome.CONCLUSIONS:
Positive fluid balance during TH in neonates with HIE is independently associated with death or moderate-to-severe brain injury on MRI.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas
/
Hipóxia-Isquemia Encefálica
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article